Enzyme Inhibition – Proteins And Enzymes – Biochemistry

Km value is defined as?
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Substrate concentration at Vmax/2

Km of an enzyme?
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Substrate concentration at half maximal velocity

Low Km means?
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High affinity

In competitive inhibition?
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Vmax unchanged

Competitive inhibition?
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Increased Km, Vmax remain same

Km Changes, Vmax is same?
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Competitive Enzyme Inhibition

Competitive inhibition?
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Reversible non competitive inhibition?
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Lower Vmax, Km not affected

Non competitive inhibitor?
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Decrease Vmax

Example for non competitive enzyme inhibition?
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Cycloxygenase by aspirin
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