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Stable heritable alteration of DNA?
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Mutation

Example for Silent mutation?
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Hb Bristol

Partially acceptable mutation?
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Sickle cell anemia

Unacceptable mutation?
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Methemoglobinemia

Single base changes are seen with?
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Conserved mutation?
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Alanine to leucine

Null mutation?
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Mutation that leads to no functional gene product

Base substitution of GAC(asp) to GAG(glu)?
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Point mutation, Conserved mutation

NOT true about base substitution mutation?
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Reading frame changes downstream to mutant site

Missense mutation occurs in?
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Hemoglobin S
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