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Pharmacology FMGE Past Paper Questions

Pharmacology FMGE Past Paper Questions: High yield subject in the FMGE/MCI exam with 13 marks from pure Pharmacology & 10 more marks shall be expected from related subjects like IM in FMGE/MCI exam.

Regarding efficacy and potency of a drug, all are true, except:

In a clinical setup, efficacy is more important than potency

In the log dose response curve, the height of the curve corresponds with efficacy

ED50 of the drug corresponds to efficacy

Drugs that produce a similar pharmacological effect can have different levels of efficacy

Correct! Wrong!

All the following are selective beta blockers, except:

Atenolol

Esmolol

Bisprolol

Celiprolol

Correct! Wrong!

All of the following factors increase the risk of aminoglycoside renal toxicity, except:

Elderly person

Dehydration

Simultaneous use with penicillin

Aminoglycoside administration in recent past

Correct! Wrong!

In which of the following disorders is administration of barbiturates contraindicated in:

Anxiety disorders

Acute intermittent porphyria

Kemincterus

Refractive status epilepticus

Correct! Wrong!

Mechanism of action tianeptin in the brain is:

Selective serotonin reuptake inhibition

Selective norepinephfine reuptake inhibition

Selective serotonin reuptake enchancer

Selective dopamine reuptake inhibition

Correct! Wrong!

Proton pump inhibitors are most effective when they are given:

After meals

Shortly before meals

Along with H2 blockers

During prolonged fasting periods

Correct! Wrong!

Which of the following is correctly matched:

Dimercaprol: Iron

Calcium di-sodium EDTA: Arsenic

Penicillamine: Copper

Desferrioxamine: Lead

Correct! Wrong!

Digoxin is contraindicated in:

Supraventricular tachycardia

Atrial fibrillation

Congestive heart failure

Hypertrophic obstructive cardiomyopathy

Correct! Wrong!

All the following drugs cause renal failure except:

Cephaloridine

Amphoterecin B

Cefoperazone

Gentamicin

Correct! Wrong!

All of the following statements are true regarding losartan except:

It is a competitive angiotensin receptor antagonist

It has a long acting metabolite

Associated with negligible cough

Causes hyperuricemia

Correct! Wrong!

Gemcitabine is effective in:

Head and neck cancers

Pancreatic cancer

Small-cell lung cancer

Soft tissue sarcoma

Correct! Wrong!

All of the following drugs can cross placenta except:

Phenytoin

Diazepam

Morphine

Heparin

Correct! Wrong!

A highway truck driver has profuse rhinorrhea and sneezing. Which among the following drugs would you prescribe him?

Pheniramine

Promethazine

Dimerhydrinate

Cetrizine

Correct! Wrong!

The mechanism of action of sodium nitroprusside is:

Increased cAMP

Increased guanylate cyclase

Calcium channel blockage

K+ channel opener

Correct! Wrong!

All the following belong to the steroid receptor superfamily except:

Vitamin D3 receptor

Thyroid receptor

Retinoid receptor

Epinephrine receptor

Correct! Wrong!

All of the following undergo hepatic metabolism before excretion except:

Phenytoin

Diazepam

Penicillin G

Cimetidine

Correct! Wrong!

In a patient taking oral contraceptive, the chance of pregnancy increases after taking any of the following drugs except:

Phenytoin

Carbamazepine

Ampicillin

Cimetidine

Correct! Wrong!

The primary mechanism of action of fluoride on the topical application is:

Conversion of hydroxyapatite to fluoroapatite by replacing the – OH ions

Inhibition of plaque bacteria

Form a reservoir in saliva

Improvement in tooth morphology

Correct! Wrong!

A 65 year old man was consuming opium for 20 years. He stops consumption suddenly and comes to casualty after 2 days. Which is likely to occur due to withdrawal:

Rhinorrhoea

Hypotension

Drowsiness

Miosis

Correct! Wrong!

Which of the following causes hepatic granuloma?

Amiodarone

Alcohol

Cimetidine

Metronidazole

Correct! Wrong!

Coronary steal commonly is seen with:

Atenolol

Diltiazem

Nitroglycerine

Dipyridamole

Correct! Wrong!

A patient is taking ketoconazole for fungal infection develops cold for which he is prescribed terfenadine. Possible interaction between terfenadine and ketoconazole is:

Ketoconazole decreases metabolism of terfenadine

Terfenadine increases levels of ketoconazole

Ketoconazole decreases levels of terfenadine

No interaction

Correct! Wrong!

Granulocytopenia, gingival hyperplasia and facial hirsutism are all possible side effects of one of the following anticonvulsant drugs:

Phenytoin

Valproate

Carbamazepine

Phenobarbitone

Correct! Wrong!

Bacitracin acts on:

Cell wall

Cell membrane

Nucleic acid

Ribosomes

Correct! Wrong!

All of the following drugs act on cell membrane, except:

Nystatin

Griseofulvin

Amphotericin B

Polymixin B

Correct! Wrong!

The extent to which ionization of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is not correct:

pKa of a drug is the pH at which the drug is 50% ionized.

Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionization.

Knowledge of pKa of a drug is useful in predicting its behaviour in various body fluids.

Phenobarbitone with a pKa of 7.2 is largely ionized at acid pH and will be about 40% non-ionised in plasma.

Correct! Wrong!

Presence of food might be expected to interfere with drug absorption by slowing gastric emptying, or by altering the degree of ionisation of the drug in the stomach. Which of the following statement is not correct example:

Absorption of digoxin is delayed by the presence of food.

Concurrent food intake may severely reduce the rate of absorption of phenytoin.

Presence of food enhances the absorption of hydrochlorothiazide.

Antimalarial drug halofantrine is more extensively absorbed if taken with food.

Correct! Wrong!

Bosentan is a:

Serotonin uptake inhibitor

Endothelin receptor antagonist

Leukotriene modifier

Calcium sensitizer

Correct! Wrong!

All are reasons for reducing drug dosage in elderly except:

They are lean and their body mass is less

Have decreasing renal function with age

Have increased baroceptor sensitivity

Body water is decreased

Correct! Wrong!

True statement regarding inverse agonists is:

Binds to receptor and causes intended action

Binds to receptor and causes opposite action

Binds to receptor and causes no action

Binds to receptor and causes submaximal action

Correct! Wrong!

PHARMACOLOGY FMGE PAST PAPER QUESTIONS

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Pharmacology FMGE Past Paper Questions

Pharmacology FMGE Past Paper Questions: High yield subject in the FMGE/MCI exam with 13 marks from pure Pharmacology & 10 more marks shall be expected from related subjects like IM in FMGE/MCI exam.

Regarding efficacy and potency of a drug, all are true, except:

All the following are selective beta blockers, except:

All of the following factors increase the risk of aminoglycoside renal toxicity, except:

In which of the following disorders is administration of barbiturates contraindicated in:

Mechanism of action tianeptin in the brain is:

Proton pump inhibitors are most effective when they are given:

Which of the following is correctly matched:

Digoxin is contraindicated in:

All the following drugs cause renal failure except:

All of the following statements are true regarding losartan except:

Gemcitabine is effective in:

All of the following drugs can cross placenta except:

A highway truck driver has profuse rhinorrhea and sneezing. Which among the following drugs would you prescribe him?

The mechanism of action of sodium nitroprusside is:

All the following belong to the steroid receptor superfamily except:

All of the following undergo hepatic metabolism before excretion except:

In a patient taking oral contraceptive, the chance of pregnancy increases after taking any of the following drugs except:

The primary mechanism of action of fluoride on the topical application is:

A 65 year old man was consuming opium for 20 years. He stops consumption suddenly and comes to casualty after 2 days. Which is likely to occur due to withdrawal:

Which of the following causes hepatic granuloma?

Coronary steal commonly is seen with:

A patient is taking ketoconazole for fungal infection develops cold for which he is prescribed terfenadine. Possible interaction between terfenadine and ketoconazole is:

Granulocytopenia, gingival hyperplasia and facial hirsutism are all possible side effects of one of the following anticonvulsant drugs:

Bacitracin acts on:

All of the following drugs act on cell membrane, except:

The extent to which ionization of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is not correct:

Presence of food might be expected to interfere with drug absorption by slowing gastric emptying, or by altering the degree of ionisation of the drug in the stomach. Which of the following statement is not correct example:

Bosentan is a:

All are reasons for reducing drug dosage in elderly except:

True statement regarding inverse agonists is:

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