Categories: FMGE Case Based QuestionsMicrobiology FMGE Questions

Microbiology FMGE Case Based Questions

A student has a genetic defect and cannot produce the J chain which is important in the structure of some immunoglobulin molecules. Which of the following will most likely be observed in this individual?

a decrease in mature B cells

a decrease in mature T lymphocytes

a decrease in serum IgM

an increase in IgA in the intestine

Correct! Wrong!

A 10-year-old boy has a bacterial pneumonia. The etiologic agent had M type-1 protein and grew on blood agar. The patient’s immune system appeared incapable of controlling the infection. A decrease in which of the following is most directly related to the immunological failure?

antibody activity

cytotoxic T-cell function

IL-4 and IL-10 levels

mast cell degranulation

Correct! Wrong!

An emaciated prisoner in a New York prison began coughing up sputum streaked with blood. Examination of the sputum revealed the presence of acid-fast bacilli. Which of the following would be least helpful in establishing a diagnosis of tuberculosis?

agglutination test for antibodies

niacin production test

nitrate reduction test

rough, non-pigmented colonies

Correct! Wrong!

Following the consumption of fish at a local restaurant, a 17-year-old girl suddenly experiences severe dyspnea. Upon arrival at the local emergency room she is found to be severely hypotensive and in respiratory distress. Urticarial wheals are also noted all over her body. As the resident physician you quickly realize this to be a hypersensitivity reaction. To which of the following immunoglobulins does the allergen bind rapidly during the activation stage of mast cells?

IgA

IgD

IgE

IgG

Correct! Wrong!

Physical examination reveals severe laryngeal edema resulting in a marked hoarseness when the 17-year-old girl attempts to speak. Also, her lips and tongue show significant swelling. Which of the following chemicals most likely caused this edematous swelling?

corticosteroids

cromolyn sodium

epinephrine

histamine

Correct! Wrong!

In February, three patients from a nursing home in East Dallas develop an abrupt onset of a febrile upper respiratory tract illness. They have received no immunizations in the last year. Culture of the nasopharynx of one patient shows influenza A virus. To prevent further cases within the next two weeks, which of the following should be administered?

acyclovir

amantadine

hyperimmune serum globulin

influenza A vaccine

Correct! Wrong!

Which of the following statements best describes interferon’s suspected mode of action in producing resistance to viral infection?

It alters the permeability of the cell membrane so that viruses cannot enter the cell

It stimulates a cell-mediated immunity

It stimulates humoral immunity

Its action is related to the synthesis of a protein that inhibits mRNA function

Correct! Wrong!

A 25-year-old man with acquired immune deficiency disease (AIDS) has malabsorption, chronic abdominal pain, low-grade fever, and nonbloody diarrhea. In fecal smears, large numbers of oocysts containing four sporozoites were observed. Which of the following organisms is most likely the etiological agent?

Cryptosporidium parvum

Entamoeba histolytica

Giardia lamblia

Microsporidia species

Correct! Wrong!

A 38-year-old sexually-active woman developed symptoms of lower abdominal pain with adjacent tenderness. No gram-negative cocci were observed or isolated. The obligate intracellular organism causing the infection is unable to perform which of the following metabolic functions?

form ATP

form the intracellular, metabolically active, reticulate body

produce polypeptides

reproduce by binary fission

Correct! Wrong!

Severe septic infections caused by bacteriapossessing capsules often occur following splenectomy. Which of the following statements most accurately explains why this medical complication is able to occur?

The spleen is a source of IgM and IgG antibodies needed to opsonize encapsulated bacteria.

The spleen is the main source of stem cells.

The spleen is uniquely equipped to process capsular polysaccharides.

The spleen rapidly inactivates many antimicrobial agents.

Correct! Wrong!

Microbiology FMGE Case Based Questions

How to Prepare Microbiology for FMGE?	How to Prepare Microbiology for FMGE?

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Microbiology FMGE Case Based Questions

Microbiology FMGE Case Based Questions

A student has a genetic defect and cannot produce the J chain which is important in the structure of some immunoglobulin molecules. Which of the following will most likely be observed in this individual?

A 10-year-old boy has a bacterial pneumonia. The etiologic agent had M type-1 protein and grew on blood agar. The patient’s immune system appeared incapable of controlling the infection. A decrease in which of the following is most directly related to the immunological failure?

An emaciated prisoner in a New York prison began coughing up sputum streaked with blood. Examination of the sputum revealed the presence of acid-fast bacilli. Which of the following would be least helpful in establishing a diagnosis of tuberculosis?

Physical examination reveals severe laryngeal edema resulting in a marked hoarseness when the 17-year-old girl attempts to speak. Also, her lips and tongue show significant swelling. Which of the following chemicals most likely caused this edematous swelling?

Which of the following statements best describes interferon’s suspected mode of action in producing resistance to viral infection?

A 38-year-old sexually-active woman developed symptoms of lower abdominal pain with adjacent tenderness. No gram-negative cocci were observed or isolated. The obligate intracellular organism causing the infection is unable to perform which of the following metabolic functions?

Severe septic infections caused by bacteriapossessing capsules often occur following splenectomy. Which of the following statements most accurately explains why this medical complication is able to occur?

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